The Nintendo Wii game system has a powerful remote controller called the Wiimote. It's pretty demanding, physically, but CATEA at Georgia Tech has developed some interesting Wiimote modifications that you can build yourself.
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The Accessible Technology Coalition is a project of the Center for Accessible Technology, and is made possible with generous funding from the American Recovery and Reinvestment Act within the U.S. Department of Commerce and the California Emerging Technology Fund (CETF).